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Tritace 2.5mg Tablet 1 Strip
Ramipril is a prodrug that is converted to ramiprilat, which inhibits ACE (angiotensin-converting enzyme), thereby blocking the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in vasodilation, reduced aldosterone production, and ultimately lowers blood pressure. Ramipril also offers cardioprotective benefits and is suitable for long-term therapy due to its favorable tolerance profile
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✅ Description:
Tritace is prescribed for:
- Managing high blood pressure (hypertension), either alone or with other antihypertensive agents.
- Treating congestive heart failure, especially when combined with diuretics.
- Managing patients showing signs of heart failure following an acute myocardial infarction.
- Slowing the progression of kidney disease in both diabetic and non-diabetic patients with renal involvement.
- Reducing cardiovascular risk in individuals with a history of heart disease, stroke, peripheral vascular disease, or diabetes with at least one risk factor like microalbuminuria, hypertension, or dyslipidemia.
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✔️ Side Effects
- Dizziness, fatigue, headache, and weakness.
- Less common:
- Cough, gastrointestinal disturbances, rash, anxiety, and oliguria.
- Rare but serious:
- Angioedema, anaphylaxis, hyperkalemia.
✔️ Dosage & Administration
Dosage should be tailored based on clinical response and tolerance.
For Hypertension:
Initial: 1.25–2.5 mg once daily (if not on a diuretic).
Maintenance: 2.5–20 mg/day (single or divided doses).
Post-MI Heart Failure:
Start within 48 hours: 2.5 mg twice daily.
If hypotension occurs: reduce to 1.25 mg twice daily.
Target: up to 5 mg twice daily.
Cardiovascular Risk Reduction:
Week 1: 2.5 mg once daily.
Weeks 2–4: 5 mg once daily.
Maintenance: up to 10 mg once daily.
Renal Impairment:
Hypertension: Start with 1.25 mg daily, max 5 mg/day.
Heart failure: Start with 1.25 mg daily, may increase up to 2.5 mg twice daily.
Administration: Swallow whole with water. May be taken with or without food. Do not crush or chew.
✔️ Interactions
- Diuretics: May lead to hypotension or hyperkalemia (with potassium-sparing types).
- Lithium: Risk of elevated serum lithium levels.
- NSAIDs: May diminish antihypertensive efficacy and impair renal function.
- Alcohol: Can enhance blood pressure-lowering effects.
✔️ Contraindications
- Known allergy to ramipril or other ACE inhibitors.
- History of angioedema.
- Use with sacubitril/valsartan, aliskiren in diabetic or renally impaired patients.
- Renal artery stenosis, hypotension, or hemodynamic instability.
- Pregnancy and lactation.
- During extracorporeal therapies using negatively charged membranes (e.g., certain dialysis filters).
✔️ Use in Pregnancy & Lactation
Contraindicated in pregnancy due to risk of fetal harm. Avoid in breastfeeding mothers.
✔️ Precautions
Use cautiously in:
- Renal or hepatic impairment
- Electrolyte imbalances (especially hyperkalemia)
- Hypotensive conditions
- Special Populations:
- Elderly: Start at 1.25 mg daily.
- Liver dysfunction: Max dose 2.5 mg/day.
- Renal dysfunction: Adjust dose based on creatinine clearance.
- Prior diuretic use: Consider discontinuation or dose reduction before starting Tritace.
✔️ Storage
Store below 30°C, away from light. Keep out of children’s reach. Use only as prescribed and before the expiry date.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
